Alzheimer's Disease Neuroimaging Initiative Selected Research

Disease Progression

1/2022	Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.
1/2022	Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.
11/2021	Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer's disease dementia.
11/2021	DeepAtrophy: Teaching a neural network to detect progressive changes in longitudinal MRI of the hippocampal region in Alzheimer's disease.
10/2021	Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease.
1/2021	APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia.
1/2021	Associations of the Rate of Change in Geriatric Depression Scale with Amyloid and Cerebral Glucose Metabolism in Cognitively Normal Older Adults: A Longitudinal Study.
10/2020	Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease.
1/2020	Age-dependent effect of APOE and polygenic component on Alzheimer's disease.
1/2020	Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia.

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Alzheimer's Disease Neuroimaging Initiative Research Topics

Disease

447	Alzheimer Disease (Alzheimer's Disease) 07/2022 - 11/2008
239	Cognitive Dysfunction 11/2022 - 01/2009
125	Atrophy 01/2022 - 07/2008
102	Dementia (Dementias) 01/2022 - 05/2009
47	Disease Progression 01/2022 - 01/2009
13	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 11/2010
9	Amyloidosis 01/2020 - 08/2013
7	Amyloid Plaque 01/2019 - 05/2012
5	Genetic Risk Score 12/2021 - 11/2012
5	Inflammation (Inflammations) 01/2021 - 05/2014
5	Parkinson Disease (Parkinson's Disease) 01/2020 - 03/2015
5	Genetic Predisposition to Disease (Genetic Predisposition) 01/2020 - 08/2010
4	Tauopathies 01/2022 - 11/2014
4	Neuroinflammatory Diseases 01/2022 - 12/2019
4	Hypertension (High Blood Pressure) 01/2022 - 05/2010
4	Cerebral Cortical Thinning 01/2020 - 01/2016
4	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2019 - 08/2013
3	Schizophrenia (Dementia Praecox) 01/2020 - 04/2012
3	Type 2 Diabetes Mellitus (MODY) 01/2018 - 12/2014
2	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 07/2014
2	Agnosia (Visual Agnosia) 01/2021 - 01/2020
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021 - 07/2015
2	Brain Diseases (Brain Disorder) 01/2020 - 01/2018
2	Autistic Disorder (Autism) 01/2020 - 01/2019
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2019 - 07/2015
2	Neoplasms (Cancer) 01/2018 - 01/2014
2	Chronic Renal Insufficiency 01/2018 - 04/2013
2	Mental Disorders (Mental Disorder) 01/2017 - 11/2016
2	Vascular Diseases (Vascular Disease) 04/2016 - 05/2011
2	Memory Disorders (Memory Loss) 05/2015 - 01/2013
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Epilepsy (Aura) 02/2021
1	Hearing Loss (Hearing Impairment) 01/2021
1	Hypersensitivity (Allergy) 01/2021

Drug/Important Bio-Agent (IBA)

286	Biomarkers (Surrogate Marker)IBA 11/2022 - 11/2008
177	Amyloid (Amyloid Fibrils)IBA 10/2022 - 05/2009
78	Apolipoproteins E (ApoE)IBA 01/2022 - 04/2009
50	ApolipoproteinsIBA 01/2022 - 04/2009
38	Amyloid beta-PeptidesIBA 01/2022 - 04/2009
33	florbetapirIBA 07/2022 - 10/2012
32	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 05/2009
25	Biological ProductsIBA 01/2022 - 01/2010
21	Proteins (Proteins, Gene)FDA Link 07/2022 - 06/2010
19	Apolipoprotein E4IBA 10/2021 - 03/2009
12	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 12/2017 - 05/2009
11	Pharmaceutical PreparationsIBA 01/2019 - 01/2009
10	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 04/2022 - 01/2018
10	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021 - 09/2010
9	Peptides (Polypeptides)IBA 10/2017 - 04/2009
7	NeurograninIBA 01/2022 - 10/2016
7	Cholinergic Agents (Cholinergics)IBA 01/2022 - 03/2014
7	tau Proteins (tau Protein)IBA 01/2020 - 04/2009
5	Indicators and Reagents (Reagents)IBA 07/2022 - 04/2009
5	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2022 - 01/2011
5	Silver Sulfadiazine (SSD)FDA LinkGeneric 01/2020 - 04/2012
5	Pemetrexed (MTA)FDA Link 01/2019 - 07/2008
5	Blood Proteins (Serum Proteins)IBA 10/2015 - 01/2011
5	amyloid beta-protein (1-42)IBA 08/2010 - 04/2009
4	ProgranulinsIBA 01/2021 - 05/2018
4	Genetic Markers (Genetic Marker)IBA 01/2021 - 01/2014
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 10/2017 - 08/2010
4	Threonine (L-Threonine)FDA Link 01/2011 - 04/2009
3	Amino Acids FDA Link 01/2022 - 10/2009
3	pleiotrophin (HARP)IBA 02/2021 - 08/2017
3	LipidsIBA 01/2021 - 09/2014
3	Protons (Proton)IBA 01/2018 - 05/2011
3	CholesterolIBA 09/2014 - 05/2010
2	Cholinergic Antagonists (Anticholinergics)IBA 01/2022 - 10/2020
2	Uric Acid (Urate)IBA 10/2021 - 05/2016
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 07/2015
2	Mitochondrial DNA (mtDNA)IBA 01/2020 - 08/2010
2	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2019 - 11/2012
2	CarbonIBA 12/2017 - 01/2015
2	HomocysteineIBA 04/2017 - 09/2009
2	Apolipoprotein E2IBA 01/2017 - 11/2010
2	P-2 (P 2)IBA 12/2016 - 07/2011
2	IronIBA 05/2015 - 06/2010
2	Cystatin CIBA 07/2014 - 04/2013
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 05/2014 - 02/2010
2	Transferrin (beta 2 Transferrin)IBA 01/2014 - 06/2010
2	Complement Receptors (Complement Receptor)IBA 05/2012 - 07/2011
1	Donepezil (Aricept)FDA LinkGeneric 01/2022
1	CD2-associated proteinIBA 01/2022
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022
1	PotassiumIBA 01/2022
1	Apolipoproteins B (ApoB)IBA 01/2022
1	amsonic acid (DAS)IBA 11/2021
1	AntioxidantsIBA 10/2021
1	KynurenineIBA 01/2021
1	CalciumIBA 01/2021
1	ChromatinIBA 01/2021
1	Deoxyribonuclease I (Nickase)IBA 01/2021
1	Biological FactorsIBA 01/2021
1	Synaptosomal-Associated Protein 25IBA 01/2021
1	HeterochromatinIBA 01/2021
1	Histones (Histone)IBA 01/2021

Therapy/Procedure

18	Therapeutics 01/2021 - 01/2009
4	Activities of Daily Living (ADL) 01/2018 - 02/2011
2	Precision Medicine 11/2019 - 01/2018
1	Off-Label Use 01/2021